BACCHUS Publications


Cell Systems to Investigate the Impact of Polyphenols on Cardiovascular Health

Charlotte Grootaert and colleagues from Ghent (BE) and Istanbul Technical Universities (TR) have reviewed the literature concerning cell culture models for polyphenols and cardiovascular disease research … read more

Identifying the limits for ellagic acid bioavailability: A crossover pharmacokinetic study in healthy volunteers after consumption of pomegranate extracts 

Antonio González-Sarrías and colleagues from CEBAS-CSIC and the Catholic University of San Antonio(ES) have examined factors contributing to ellagic acid bioavailability in order to evaluate whether this can be improved … read more

Anthocyanin Absorption and Metabolism by Human Intestinal Caco-2 Cells—A Review

Researchers at Ghent University (BE) have reviewed the literature describing the Caco-2 cell models for testing the bioactive properties of anthocyanins and their beneficial health effects in humans … read more

 rasberries

Time Course Production of Urolithins from Ellagic acid by Human Gut Microbiota

Garcia-Villalba and colleagues from CEBAS-CSIC (ES) have conducted a study using detailed experiments in vitro and in vivo to identify the intermediary and final catabolites of ellagic acid in the human gut … read more

 

Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF: Relevance to angiogenesis

Christina W. A. Moyle and colleagues from the Institute of Food Research (IFR, UK) have demonstrate for the first time that VEGF is a key molecular target for specific polyphenols found in tea, apples and … read more

 

Interindividual variability in the human metabolism of ellagic acid: Contribution of Gordonibacter to urolithin production

Maria Romo-Vaquero and colleagues from the CEBAS-CSIC (ES) have examined the role of Gordonibacter and other human gut bacteria in human health … read more

 Bacchus-Biological significance of urolithins

Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far

Juan Carlos Espín and colleagues from CEBAS-CSIC (ES) have reviewed literature describing urolithin metabolites production by gut microbiota, their absorption, tissue distribution and pharmacokinetics, and … read more

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Ellagic Acid Metabolism by Human Gut Microbiota: Consistent Observation of Three Urolithin Phenotypes in Intervention Trials, Independent of Food Source, Age, and Health Status

Francesco Tomás-Barberán and colleagues from CEBAS-CSIC(ES) have described three phenotypes for urolithin production, after intake of ellagitannin and ellagic acid. The proposed phenotypes could explain inter-individual variability … read more

 Tea

Inhibition of VEGF Signaling by Polyphenols in Relation to Atherosclerosis and Cardiovascular Disease in Recent Advances in Polyphenol Research

Rebecca Edwards and Paul Kroon with colleagues from the Institute of Food Research (UK) have reviewed the literature describing the potential for polyphenols to influence atherosclerosis … read more

 Pom

Validated Method for the characterization and quantification of extractable and non-extractable ellagitannins after acid hydrolysis in pomegranate fruits, juices, and extracts

Rocio Garcia-Villalba and colleagues from CEBAS-CSIC (ES) have developed a new method for the analysis of the extractable and non-extractable ellagitannins, based on the quantification of acid hydrolysis products … read more

 

Nutrition and health claims in practice

Judith Buttriss, Director General at the British Nutrition Foundation (UK) describes progress with implementation of the EU nutrition and health claims process, which covers all foods, drinks and dietary supplements sold in the EU and was established to ensure that claims about the nutritional or health attributes of products are substantiated by robust scientific evidence and can be relied upon by consumers … read more

 Chocolate Image

The cardiovascular benefits of dark chocolate

Asimina Kerimi and Gary Williamson from the University of Leeds (UK) have found that human intervention studies analysing chocolate consumption are complicated by metabolic dysfunction amongst participants and limited molecular knowledge of flavanols. Their review concluded that future research on chocolate should focus on the effects of individual components on human health … read more

 Legume Image

Bioactive Peptides in Cereals and Legumes: Agronomical, Biochemical and Clinical Aspects

Arrigo F. G. Cicero and colleagues from the Departments of Life Quality Studies, Agricultural Sciences and Medicine and Surgery from Alma Mater Studiorum University of Bologna (IT) have conducted a review examining approaches for assessing effects of bioactive peptides from cereals and legumes. They determined that the best in vivo methods used activity-guided fractionation, where separation of protein-digested fractions is combined with an evaluation of specific biological activity in vivo … read more

 Pomegranate Image

Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients

Maria Nunez-Sanchez and colleagues from Quality, Safety and Bioactivity of Plant Foods (Campus de Espinardo, ES) and the Nutrition, Digestion, Surgery and Anatomical Pathology Services (Hospital Reina Sofia, Murcia, ES) found that colorectal cancer cells taken from patients who had consumed pomegranate extract (PE) contained bioactive polyphenols, such as ellagic acid (EA) and urolithins … read more

 Wheat Picture

Lunasin in wheat: A chemical and molecular study on its presence or absence

Giovanni Dinelli and colleagues from Alma Mater Studiorum University of Bologna (IT), Bioaesis (IT) and Kamut International (USA) have confirmed there is no lunasin, nor any lunasin-like compound(s) with similar molecular weight(s), present in various wheat genotypes … read more

 Meat Picture

Optimisation of a simple and reliable label-free methodology for the relative quantitation of raw pork meat proteins

Marta Gallego and colleagues from Instituto de Agroquímica y Tecnología de Alimentos (CSIC) (ES) have developed a rapid, simple, and reliable method to quantify changes in protein abundance in meat. This method will help identify bioactive proteins with potential health benefits. Proteomics is the study of the entire complement of proteins that is or can be expressed by a cell, tissue or organism … read more

 Spanish ham Image

Stability of ACE inhibitory ham peptides against heat treatment and in vitro digestion

Elizabeth Escudero, Leticia Mora, Fidel Toldrá from Instituto de Agroquímica y Tecnología de Alimentos (CSIC, ES) have confirmed that peptides from dry-cured Designation of Origin of Teruel ham (D.O. Teruel, Spain) are stable after processing and digestion, and retain powerful Angiotensin I-converting enzyme (ACE) inhibitory activity. Dietary proteins can help maintain or improve health following processing or digestion … read more

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Molecular structure-function relationship of dietary polyphenols for inhibiting VEGF-induced VEGFR-2

The Polyphenols and Health Group, led by Dr Paul Kroon, from the Institute of Food Research (UK), and Ana Cerezo from Nutrición y Bromatología, Facultad de Farmacia (Universidad de Sevilla, ES) have shown that some polyphenols bind directly with vascular endothelial growth factor (VEGF), which inhibits atherosclerosis and, therefore, progression of cardiovascular disease (CVD) … read more

 Dry ham

Transepithelial transport of dry-cured ham peptides with ACE inhibitory activity through a Caco-2 cell monolayer

Marta Gallego and colleagues from the Instituto de Agroquímica y Tecnología de Alimentos (CSIC, ES) and the Ghent University (BE) have examined the stability of naturally occurring angiotensin converting enzyme (ACE)-inhibitors in dry-cured ham during intestinal trans-epithelial transport using a Caco-2 cell monolayer…read more

 


Peer Reviewed Publications

González-Sarrías et. al. (2017), Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight-obese individuals consuming pomegranate: A randomized clinical trial, Molecular Nutrition and Food Research, 2017, DOI: 10.1002/mnfr.201600830, http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201600830/abstract

González-Sarrías A. et. al. (2017), Antiproliferative activity of the ellagic acid-derived gut microbiota isourolithin A and comparison with its urolithin A isomer: the role of cell metabolism, Eur J Nutr. 2017 Mar; 56(2): 831-841, DOI: 10.1007/s00394-015-1131-7-015-1131-7 , http://link.springer.com/article/10.1007%2Fs00394-015-1131-7

González-Sarrías A. et. al. (2017), Neuroprotective effects of bioavailable polyphenol-derived metabolites against oxidative stress-induced cytotoxicity in human neuroblastoma SH-SY5Y cells, J. Agric. Food Chem. 2017, 65, 752-758, DOI: 10.1021/acs.jafc.6b04538,  http://pubs.acs.org/doi/abs/10.1021/acs.jafc.6b04538

Kardum N. et. al. (2017), Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies, International Journal of Food Sciences and Nutrition Published online: 01 Feb 2017, Doi:10.1080/09637486.2017.1283682,http://www.tandfonline.com/doi/abs/10.1080/09637486.2017.1283682?journalCode=iijf20

Selma M. V. et. al. (2017), The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two main urolithin metabotypes that correlate with cardiometabolic risk biomarkers: comparison between normoweight, overweight-obese and metabolic syndrome subjects, Clinical Nutrition, 2017, http://www.clinicalnutritionjournal.com/article/S0261-5614(17)30103-6/fulltext?rss=yes

Tumova S. et. al. (2017), Transendothelial glucose transport is not restricted by extracellular hyperglycaemia, Vascular Pharmacology, 2016, 87: 219-229, http://dx.doi.org/10.1016/j.vph.2016.11.001, http://eprints.whiterose.ac.uk/107240/

Van Rymenant E. et. al. (2017), Chronic exposure to short chain fatty acids modulates transport and metabolism of microbiome-derived phenolics in human intestinal cells, Journal of Nutritional Biochemistry, 2017, 39: 156-168, http://www.jnutbio.com/article/S0955-2863(16)30399-0/abstract

Walker M. et. al. (2017), Health and nutrition claims – guidance, regulation and self-regulation, Nutrition Bulletin 2017, 42: 69-79, doi: 10.1111/nbu.12251     , http://onlinelibrary.wiley.com/doi/10.1111/nbu.12251/abstract

Kerimi A. et. al. (2016), At the interface of antioxidant signalling and cellular function: key polyphenol effects, Molecular Nutrition and Food Research, 60, 1770-1788, DOI: 10.1002/mnfr.201500940, http://dx.doi.org/10.1002/mnfr.201500940

Lucey A. et. al. (2016), Guidance for the design and implementation of human dietary intervention studies for health claim submissions, Nutrition Bulletin, accepted for publication , DOI: 10.1111/nbu.12241, http://onlinelibrary.wiley.com/doi/10.1111/nbu.12241/full

Selma M. V. et. al. (2016), The human gut microbial ecology associated to overweight and obesity determines ellagic acid metabolism, Food & Function, April 2016 7(4):1769-74, DOI: 10.1039/C5FO01100K, http://pubs.rsc.org/en/Content/ArticleLanding/2016/FO/C5FO01100K#!divAbstract

Toldrá F. et. al. (2016), Characterisation of the peptide profile of Spanish Teruel, Italian Parma and Belgian dry-cured hams and its potential bioactivity, Food Research International, 2016, 89, 638-646, http://www.sciencedirect.com/science/article/pii/S0963996916304069

Toldrá F. et. al. (2016), Peptidomics as a tool for quality control in dry-cured ham processing, Journal of Proteomics, 2016, 147, 98-107 http://www.sciencedirect.com/science/article/pii/S1874391916300422

Tomas-Barberan F. A. et. al. (2016), Urolithins, the rescue of ‘old’ metabolites to understand a ‘new’ concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status, Molecular Nutrition and Food Research 2017, 61, 1, DOI: 10.1002/mnfr.201500901, http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201500901/abstract

Tomas-Barberan F. A. et. al. (2016), Interactions of gut microbiota with dietary polyphenols and consequences to human health, Curr. Opin. Clin. Nutr. Metab. Care, DOI: 10.1097/MCO.0000000000000314, http://journals.lww.com/co-clinicalnutrition/pages/articleviewer.aspx?year=2016&issue=11000&article=00012&type=abstract

Buttriss J. et. al. (2015), Nutrition and health claims in practice, Nutrition Bulletin, 40, 211–222. , DOI: 10.1111/nbu.12155, http://onlinelibrary.wiley.com/doi/10.1111/nbu.12155/abstract

Garcia-Villalba, R. et al. (2015), Validated method for the characterization and quantification of extractable and non-extractable ellagitannins after acid hydrolysis in pomegranate fruits, juices, and extracts, Agric. Food Chem., 63(29): 6555–6566

Gonzalez-Sarrias A. et al. (2015), Identifying the limits for ellagic acid bioavailability: a crossover pharmacokinetic study in healthy volunteers after consumption of pomegranate extracts, J. Functional Foods, 19: 225-235

Grootaert C. et al. (2015), Cell Systems to Investigate the Impact of Polyphenols on Cardiovascular Health, Nutrients, 7: 1-28

Kamiloglu S. et. al. (2015), Anthocyanin Absorption and Metabolism by Human Intestinal Caco-2 Cells – A Review, Int. J. Mol. Sci. 2015, 16(9), 21555-21574, doi:10.3390/ijms160921555, http://www.mdpi.com/1422-0067/16/9/21555

Kamiloglu S. et al. (2015), Anthocyanin Absorption and Metabolism by human Instestinal Caco-2 Cells – A Review, Int. J. Mol. Sci, 16(9): 21555-21574

Kerimi A. et. al. (2015), The cardiovascular benefits of dark chocolate, Vascular Pharmacology, 2015, 71, Pages 11–15, doi:10.1016/j.vph.2015.05.011,  https://doi.org/10.1016/j.vph.2015.05.011

Kronic Ristic A. et. al. (2015), Modulation of platelet function with dietary polyphenls – A promising strategy in the prevention of cardiovascular disease, Agro Food Industry Hi Tech; 2015;26(2):16-19, http://old.teknoscienze.com//Contents/Riviste/Sfogliatore/AF2_2015/index.html#16

Mora L. et al. (2015), A peptidomic approach top study the contribution of added casein proteins to the peptides profile in Spanish dry-fermented sausages, International Journal of Food Microbiology (special issues for meat symposium), 212: 41-48

Romo-Vaquero M. et al. (2015), Interindividual variability in the human metabolism of ellagic acid: contribution of Gordonibacter to urolithin production, J. Functional Foods, 17: 785-791

Cicero A. et. al. (2014), Bioactive peptides in cereals and legumes: Agronomical, biochemical and clinical aspects, Int J Mol Sci. 2014 Nov; 15(11): 21120–21135, doi:  10.3390/ijms151121120,  https://dx.doi.org/10.3390%2Fijms151121120

Espin J. C. et. al. (2014), Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients, Molecular Nutrition and Food Research. Mol. Nutr. Food Res. 2014, 00, 1–13 Accepted Feburary 2014, DOI: 10.1002/mnfr.201300931, http://www.sciencedirect.com/science/article/pii/S0308814613018074

Kroon P. A. et. al. (2014), Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF: Relevance to angiogenesis, Molecular Nutrition and Food Research. Mol. Nutr. Food Res. 2015, 59, 401-412, doi: 10.1002/mnfr.201400478, http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201400478/abstract

Toldrá F. et. al. (2014), Stability of ACE inhibitory ham peptides against heat treatment and in vitro digestion, Food Chemistry, 2014, 161, 305-311, doi:10.1016/j.foodchem.2014.03.117,  https://doi.org/10.1016/j.foodchem.2014.03.117

Tomás-Barberán F. A. et al. (2014), Ellagic Acid Metabolism by Human Gut Microbiota: Consistent Observation of Three Urolithin Phenotypes in Intervention Trials, Independent of Food Source, Age, and Health Status, Agric. Food Chem., 62(28): 6535-6538

Edwards R. L. et al. (2013), Inhibition of VEGF signalling by polyphenols in relation to atherosclerosis and cardiovascular disease, Recent Advances in Polyphenol Research IV, DOI: 10.1002/9781118329634.ch9

Dinelli G. et. al. (2013), Lunasin in wheat kernels: a chemical and molecular study on the absence or presence of the peptide, Available online 27th November 2013: Published Food Chemistry, Volume 151, 15 May 2014, Pages 520-525, doi:10.1016/j.foodchem.2013.11.119, http://www.sciencedirect.com/science/article/pii/S0308814613018074

Tomás-Barberán F. A. et al. (2013), Biological significance of urolithins, the Gut Microbial Ellagic Acid-derived metabolites: the evidence so far, Evidence-Based Complementary and Alternative Medicine, 2013: http://dx.doi.org/10.1155/2013/270418

Tomás-Barberán F. A. et al. (2013), Time Course Production of Urolithins from Ellagic acid by Human Gut Microbiota, Agric. Food Chem., 61(37): 8797–8806


Book Chapter

Tomas-Barberan F. A. et. al.  (2016), Gut microbiota metabolism, bioavailability and health benefits of pomegranate ellagitannins-derived urolithins, Pomegranate: Chemistry, Processing and Health, ISBN 978-1-63485-687-4, https://www.novapublishers.com/catalog/product_info.php?products_id=59141&osCsid=263867d043ef481530fa3926c86a39b3


Other Dissemination Activities

Toldra F. et al. (2015), 2nd International Symposium on Fermented Meat, Intl. J. Food Micro., 212: 1 doi:10.1016/j.ijfoodmicro.2015.06.007