ProDigest

ProDigest BVBA BE

Organisation type: SME

Web : www.prodigest.eu

Profile:

ProDigest BVBA is a spin-off company of Ghent University that provides professional services in the field of gastrointestinal transit, bioavailability and metabolism of food compounds and pharmaceuticals, in relation to their final functionality in the body. ProDigest was created in September 2008 based on 20 years of experience in the gastrointestinal microbial ecology of the Laboratory of Microbial Ecology and Technology (LabMET) at the Faculty of Bioscience Eng. at Ghent University. During its first 3 years, ProDigest has been involved in more than 50 research projects with the main actors in the functional food sector (fee-for-service). These projects have been aimed at the evaluation of the effect of food ingredients in the GIT in relation to bioavailability, immunology, microbial activity and the final effect on the human host. ProDigest uses a scientifically validated technology platform based on in vitro systems (Simulator of Human Intestinal Microbial Ecosystem – SHIME) to simulate the complete digestive gastrointestinal tract (GIT), and the host-microbiota interaction (bacterial adhesion and host response in terms of immunology, inflammation…). These analyses are coupled with a wide set of molecular techniques to investigate the microbial community structure and composition as well as chemical analyses (HPLC, GC, GC-MS…) to estimate the microbial community activity. The pre-clinical phase is normally followed by the organization of human trials in order to validate the in vitro findings.

Main roles in BACCHUS:

WP4: WPL and will be task leader for the evaluation of the intestinal fate of food ingredients, bioavailability of bioactives and their metabolites and the relation with human health; and assist the development of an unique Bioavailability Platform based on in vitro model systems to link intestinal metabolism of peptides and polyphenols with their bioavailability and activity towards biomarkers for cardiovascular health.